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Pharmacology: Pharmacodynamics: This product combines the potent anti-inflammatory and antiallergic action of betamethasone sodium phosphate with the broad-spectrum antibacterial activity of gentamicin sulfate.
Betamethasone, a synthetic derivative of prednisolone, offers the advantage over other corticosteroids of enhanced anti-inflammatory effects with the use of lower dosages.
Betamethasone disodium phosphate exerts its topical anti-inflammatory effect in the eye by suppressing cellular and fibrinous exudation and by normalizing the excessive permeability of inflamed capillaries.
In-vivo, staphylococcal species have responded favorably to gentamicin sulfate.
In-vitro, gentamicin sulfate is active against a wide variety of pathogenic gram-negative and some gram-positive bacteria: Coagulase-positive and coagulase-negative staphylococci, Escherichia coli, Proteus sp (indole-positive and indole-negative), Pseudomonas aeruginosa, species of Klebsiella-Enterobacter-Serratia group, and species of Citrobacter, Salmonella, Shigella, Moraxella, Serratia, and Neisseria particularly the gonococcus.
Pharmacokinetics: Eye: Gentamicin may be absorbed in minute quantities following topical application. Betamethasone is absorbed into the aqueous humor, cornea, iris, choroid, ciliary body and retina. Systemic absorption occurs but may be significant only at higher dosages or in extended paediatric therapy.
Ear: Gentamicin may be absorbed following topical application if the eardrum is perforated or tissue damage is present. There is no relevant information available for betamethasone.
